Potential SPIDER partners / other epidemiology projects

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Contents 1 Potential SPIDER partners 2 Other epidemiology projects 2.1 WHO Global Health Atlas 3 Other contacts

Potential SPIDER partners

Dominic Kwiatkowski Wellcome Trust Centre for Human Genetics, Oxford OX3 7BN Email: dominic@well.ox.ac.uk Phone: +44 1865 287654

• We're using the diversity of the human genome as a tool to identify genes that are critical for protective immunity against infection, and to discover molecular mechanisms by which the immune system is regulated. By understanding how children naturally fight infection, we hope to learn how to make effective vaccines. Our primary goal is to discover mechanisms of protective immunity against malaria, the leading cause of childhood death in Africa.

• I have a joint appointment at Oxford University where I'm MRC Clinical Research Professor in the Department of Paediatrics, and at the Wellcome Trust Sanger Institute which I joined in 2006 to lead the malaria programme.

• Our research group aims to bring together the complementary strengths of Sanger (where we're Team 112) and Oxford (where we're the WTCHG Childhood Infection Lab), combining high-throughput genomic approaches with large-scale clinical studies to learn about biological mechanisms of disease.

• One of our major tasks is to coordinate MalariaGEN, a network of malaria researchers in 20 countries that aims to accelerate vaccine development by discovering natural mechanisms of protective immunity.

Other epidemiology projects

===MalariaGEN Oxford=== (http://www.malariagen.net/perl/tennis/tennis_entry?dest=go;p=432;d=2;hdcon=information, link)

WHO Global Health Atlas

http://www.who.int/globalatlas/

Other contacts

Leonard Munstermann, Yale, School of Public Health http://publichealth.yale.edu/faculty/munstermann.html

• Senior Research Scientist, Division of Epidemiology of Microbial Diseases
• Phone: (203) 785-5533, leonard.munstermann@yale.edu

• Tools of molecular genetics focused on the insect vector provide clues to genomic organization, population structure and evolutionary relationships. Dr. Munstermann’s research emphasizes three genetic approaches: (1) Gene linkage mapping provides genetic backbone for isolating genes and macrogenomic evolution; (2) Genetic variability within an insect species in the form of isoenzymes or DNA base pair substitutions indicate population structure, population origin or taxonomic relatedness; and (3) Identification of closely related vector species by (biochemical) genetic means. Research organisms are Aedes mosquitoes and phlebotomine sand flies of New and Old World.

Heidi Brown of Simon Hey's lab says he may know who has Leptospirosis endemicity (map) data.